Small Molecules

  • what are small molecule drugs?
    • small molecule drugs are NOT proteins, they are drugs with a chemical structure
    • currently (2019) the small molecule for IBD include the JAK (Janus Kinase) inhibitors
  • what are small molecule drugs used for treatment of IBD?
    • JAK-1 and JAK-3 inhibitor – Tofacitinib (Xeljanz) – is the Health Canada approved JAK inhibitor for treatment of ulcerative colitis
  • how is Tofacitinib taken? what kind of monitoring is required
    • it is an oral pill taken twice daily.
    • people taking Tofacitinib should have regular blood work for – blood counts, liver tests, cholesterol