January 3, 2018
Question: is there is some kind of relation between crohn’s disease and the cholestasis of pregnancy?
Answer: There has been reported linkage between having IBD (crohn’s) and liver diseases (e.g. autoimmune liver disease, primary sclerosing cholangitis). There is no clear evidence that having Crohn’s disease increases the risk of cholestasis of pregnancy, however, having an autoimmune type disease such as IBD could potentially increase one’s risk of developing complications in pregnancy. Certain medications used to treat IBD can also increase liver tests. Pregnancy related changes in metabolism and break down of medications may also affect the levels of these medications.
Therefore, it is recommended that a woman who has crohn’s disease, and particularly if on immune medications (such as azathioprine, biologics etc) be seen and followed closely by her gastroenterologist as well as a high risk obstetrician and maternal-fetal medicine specialist, in order to adjust medications, monitor the fetal growth, and prevent or treat any pregnancy-related complications.